Publications:
1. Lewis C.W., Bukhari A.B., Xiao E.J., Choi W-S., Smith J.D., Homola E., Mackey J.R., Campbell S.D., Gamper A.M., Chan G.K. Cancer cells acquire resistance to the Wee1 inhibitor Adavosertib through Myt1 upregulation. Cancer Res. 79(23): 5971-5985, 2019
2. Bukhari A.B., Lewis C.W., Pearce J.J., Luong D., Chan G.K., Gamper A.M. Inhibiting Wee1 and ATR kinases produces tumor-selective synthetic lethality and suppresses metastasis. J. Clin. Invest. 129(3):1329-1344, 2019
3. Moiseeva T., Gamper A.M., Hood B., Conrads T., Bakkenist C.J. Human DNA polymerase epsilon is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 and MMS19. DNA Repair 43: 9-17, 2016
4. Hu D., Gur M., Zhou Z., Gamper A., Hung M.C., Fujita N., Lan L., Bahar I., Wan Y. Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis. Nat. Commun. 6: 2015
5. Kwun H.J., Shuda M., Camacho C., Gamper A., Thant M., Chang Y., and Moore P.S. Restricted Protein Phosphatase 2A Targeting by Merkel Cell Polyomavirus Small T Antigen. J. Virol. 89(8):4191-200, 2015.
6. Gamper A.M., Rofougaran R., Watkins S.C., Greenberger J.S., Beumer J.H., Bakkenist C.J. ATR kinase activation in G1 phase facilitates the repair of ionizing radiation-induced DNA damage. Nucleic Acids Res. 41:10334-442013, 2013.
7. Gamper A.M., Choi S., Matsumoto Y., Banerjee D., Tomkinson A.E., Bakkenist C.J. ATM physically and functionally interacts with PCNA to regulate DNA synthesis. J. Biol. Chem. 287: 12445-12454, 2012.
8. Gamper A.M., Qiao X., Kim J., Zhang L., DeSimone M.C., Rathmell W.K., Wan Y. Regulation of KLF4 turnover reveals an unexpected tissue specific role of pVHL in tumorigenesis. Mol. Cell 45: 233-243, 2012.
9. Choi S., Gamper A.M., White J.S., Bakkenist C.J. Inhibition of ATM kinase activity does not phenocopy ATM protein disruption: implications for the clinical utility of ATM kinase inhibitors. Cell Cycle 9: 4052-4057, 2010.
10. Qiao X., Zhang L., Gamper A.M., Fujita T. Wan Y. APC/C-Cdh1: From cell cycle to cellular differentiation and genomic integrity. Cell Cycle 9: 3904 - 3912, 2010. (Review)
11. Gamper A.M., Kim J., & Roeder R.G. The STAGA subunit hADA2b is an important regulator of hGCN5 catalysis. Mol. Cell. Biol. 1: 266-80, 2009.
12. Gamper A.M., Roeder R.G. Multivalent Binding of p53 to the STAGA Complex mediates Coactivator Recruitment after UV Damage. Mol. Cell. Biol. 8: 2517-27, 2008.
13. Palhan V., Chen S., Peng G.H., Tjernberg A., Gamper A.M., Chait B.T., La Spada A.R., Roeder R.G. Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration. Proc. Natl. Sci. Acad. USA. 102: 8472-7, 2005.
14. Martinez E., Palhan V., Tjernberg A., Lymar E.S., Gamper A.M., Kundu T.K., Chait B.T., Roeder R.G. Human STAGA Complex is a Chromatin-Acetylating Transcription Coactivator that Interacts with Pre-mRNA Splicing and DNA Damage-Binding Factors In Vivo. Mol. Cell. Biol. 21: 6782-95, 2001.
15. Gamper A.M., Winger R.H., Liedl K.R., Sotriffer C.A., Varga J.M., Kroemer R.T., Rode B.M. Comparative molecular field analysis of haptens docked to the multispecific antibody IgE(Lb4). J. Med. Chem. 39: 3882-3888, 1996.
16. Winger R.H., Liedl K.R., Sotriffer C.A., Gamper A.M., Rode B.M., Kroemer R.T., Varga J.M. Prediction of IgE(Lb4)-ligand complex structures by automated docking. J. Molec. Recognition 9: 239-246, 1996.
17. Sotriffer C.A., Liedl K.R., Winger R.H., Gamper A.M., Kroemer R.T., Linthicum D.S., Rode B.M., Varga J.M. Heteroligation of a mouse monoclonal IgE antibody (La2) with small molecules, analysed by computer-aided automated docking. Mol. Immunol. 33: 129-144, 1996.
18. Armesto X.L., Canle M., Gamper A.M., Losada M., Santaballa J.A. Acid-base equilibria and decomposition of secondary (N-Cl)-alpha-amino acids. Tetrahedron 50: 10509-10520, 1994.
1. Lewis C.W., Bukhari A.B., Xiao E.J., Choi W-S., Smith J.D., Homola E., Mackey J.R., Campbell S.D., Gamper A.M., Chan G.K. Cancer cells acquire resistance to the Wee1 inhibitor Adavosertib through Myt1 upregulation. Cancer Res. 79(23): 5971-5985, 2019
2. Bukhari A.B., Lewis C.W., Pearce J.J., Luong D., Chan G.K., Gamper A.M. Inhibiting Wee1 and ATR kinases produces tumor-selective synthetic lethality and suppresses metastasis. J. Clin. Invest. 129(3):1329-1344, 2019
3. Moiseeva T., Gamper A.M., Hood B., Conrads T., Bakkenist C.J. Human DNA polymerase epsilon is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 and MMS19. DNA Repair 43: 9-17, 2016
4. Hu D., Gur M., Zhou Z., Gamper A., Hung M.C., Fujita N., Lan L., Bahar I., Wan Y. Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis. Nat. Commun. 6: 2015
5. Kwun H.J., Shuda M., Camacho C., Gamper A., Thant M., Chang Y., and Moore P.S. Restricted Protein Phosphatase 2A Targeting by Merkel Cell Polyomavirus Small T Antigen. J. Virol. 89(8):4191-200, 2015.
6. Gamper A.M., Rofougaran R., Watkins S.C., Greenberger J.S., Beumer J.H., Bakkenist C.J. ATR kinase activation in G1 phase facilitates the repair of ionizing radiation-induced DNA damage. Nucleic Acids Res. 41:10334-442013, 2013.
7. Gamper A.M., Choi S., Matsumoto Y., Banerjee D., Tomkinson A.E., Bakkenist C.J. ATM physically and functionally interacts with PCNA to regulate DNA synthesis. J. Biol. Chem. 287: 12445-12454, 2012.
8. Gamper A.M., Qiao X., Kim J., Zhang L., DeSimone M.C., Rathmell W.K., Wan Y. Regulation of KLF4 turnover reveals an unexpected tissue specific role of pVHL in tumorigenesis. Mol. Cell 45: 233-243, 2012.
9. Choi S., Gamper A.M., White J.S., Bakkenist C.J. Inhibition of ATM kinase activity does not phenocopy ATM protein disruption: implications for the clinical utility of ATM kinase inhibitors. Cell Cycle 9: 4052-4057, 2010.
10. Qiao X., Zhang L., Gamper A.M., Fujita T. Wan Y. APC/C-Cdh1: From cell cycle to cellular differentiation and genomic integrity. Cell Cycle 9: 3904 - 3912, 2010. (Review)
11. Gamper A.M., Kim J., & Roeder R.G. The STAGA subunit hADA2b is an important regulator of hGCN5 catalysis. Mol. Cell. Biol. 1: 266-80, 2009.
12. Gamper A.M., Roeder R.G. Multivalent Binding of p53 to the STAGA Complex mediates Coactivator Recruitment after UV Damage. Mol. Cell. Biol. 8: 2517-27, 2008.
13. Palhan V., Chen S., Peng G.H., Tjernberg A., Gamper A.M., Chait B.T., La Spada A.R., Roeder R.G. Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration. Proc. Natl. Sci. Acad. USA. 102: 8472-7, 2005.
14. Martinez E., Palhan V., Tjernberg A., Lymar E.S., Gamper A.M., Kundu T.K., Chait B.T., Roeder R.G. Human STAGA Complex is a Chromatin-Acetylating Transcription Coactivator that Interacts with Pre-mRNA Splicing and DNA Damage-Binding Factors In Vivo. Mol. Cell. Biol. 21: 6782-95, 2001.
15. Gamper A.M., Winger R.H., Liedl K.R., Sotriffer C.A., Varga J.M., Kroemer R.T., Rode B.M. Comparative molecular field analysis of haptens docked to the multispecific antibody IgE(Lb4). J. Med. Chem. 39: 3882-3888, 1996.
16. Winger R.H., Liedl K.R., Sotriffer C.A., Gamper A.M., Rode B.M., Kroemer R.T., Varga J.M. Prediction of IgE(Lb4)-ligand complex structures by automated docking. J. Molec. Recognition 9: 239-246, 1996.
17. Sotriffer C.A., Liedl K.R., Winger R.H., Gamper A.M., Kroemer R.T., Linthicum D.S., Rode B.M., Varga J.M. Heteroligation of a mouse monoclonal IgE antibody (La2) with small molecules, analysed by computer-aided automated docking. Mol. Immunol. 33: 129-144, 1996.
18. Armesto X.L., Canle M., Gamper A.M., Losada M., Santaballa J.A. Acid-base equilibria and decomposition of secondary (N-Cl)-alpha-amino acids. Tetrahedron 50: 10509-10520, 1994.
