Publications:
28. Sokhi S., Lewis C.W., Bukhari A.B., Hadfield J., Xiao E.J., Fung J., Yoon Y.J., Hsu W.-H., Gamper A.M.*, Chan G.K.* Myt1 overexpression mediates resistance to Cell Cycle and DNA damage checkpoint kinase inhibitors. Front. Cell Dev. Biol. 2023 Nov 2;11:1270542. *corresponding authors
27. Storozynsky Q.T., Han X., Komant S., Agopsowicz K.C., Potts K.G., Gamper A.M., Godbout R., Evans D.H., Hitt M.M. Radiation-Induced Cellular Senescence Reduces Susceptibility of Glioblastoma Cells to Oncolytic Vaccinia Virus. Cancers 2023 Jun 25;15(13):3341
26. Storozynsky Q.T., Agopsowicz K.C., Noyce R.S., Bukhari A.B., Han X., Snyder N., Umer B.A., Gamper A.M., Godbout R., Evans D.H., Hitt M.M. Radiation combined with oncolytic vaccinia virus provides pronounced antitumor efficacy and induces immune protection in an aggressive glioblastoma model. Cancer Lett. 2023 May 28;562:216169. doi: 10.1016/j.canlet.2023.216169
25. Zhou J., Kong Y.S., Vincent K.M., Dieters-Castator D., Bukhari A.B., Glubrecht D., Liu R.Z., Quilty D., Findlay S.D., Huang X., Xu Z., Yang R.Z., Zhang L., Tang E., Lajoie G., Eisenstat D.D., Gamper A.M., Fahlman R., Godbout R., Postovit L.M., Fu Y. RNA cytosine methyltransferase NSUN5 promotes protein synthesis and tumorigenic phenotypes in glioblastoma. Mol Oncol. 2023 Apr 14. doi: 10.1002/1878-0261.13434.
24. Chow B., Warkentin B., Nanda K., Ghosh S., Huang F., Gamper A.M., Menon G. Radiobiological Response to Brachytherapy: Cervical Squamous Cell Carcinoma Versus Adenocarcinoma Parameters, Quantified in Vitro. Radiotherapy and Oncology 174, S25-S26, 2022
23. Bukhari A.B, Chan G.K., Gamper A.M. Targeting the DNA Damage Response for Cancer Therapy by Inhibiting the Kinase Wee1. Front. Oncol. 2022; 12:828684.
22. Sadat S.M.A., Wuest M, Paiva I.M., Munira S., Sarrami N., Sanaee F., Yang X., Paladino M., Binkhathlan Z., Karimi-Busheri F., Martin G.R., Jirik F.R., Murray D., Gamper A.M., Hall D.G., Weinfeld M., Lavasanifar A., Nano-Delivery of a Novel Inhibitor of Polynucleotide Kinase/Phosphatase (PNKP) for Targeted Sensitization of Colorectal Cancer to Radiation-Induced DNA Damage. Front. Oncol. 2021; 11: 772920.
21. Chow B., Warkentin B., Nanda K., Huang F., Gamper A.M., Menon G., BAIRDA: A novel in vitro setup to quantify radiobiological parameters for cervical cancer brachytherapy dose estimations. Phys. Med. Biol., 2022; 67(4)
20. Chow B., Warkentin B., McEwen M., Huang F., Nanda K., Gamper A.M., Menon G., Uncertainties associated with clonogenic assays using a Cs-137 irradiator and Ir-192 afterloader: A comprehensive compilation for radiation researchers. Rad. Res. 2022, Apr 7. doi: 10.1667/RADE-21-00205.1
19. Bilyk O., Hamedi B., Dutta I., Newell M., Bukhari A.B., Gamper A.M., McVea R.C., Liu J., Schueler J., Siegers G.M., Field C.J., and Postovit L.-M.
Docosahexaenoic acid in the Inhibition of Tumor Cell Growth in preclinical models of ovarian cancer. Nutr. Cancer, 74(4):1431-1445, 2022
18. Lewis C.W., Bukhari A.B., Xiao E.J., Choi W-S., Smith J.D., Homola E., Mackey J.R., Campbell S.D., Gamper A.M., Chan G.K. Cancer cells acquire
resistance to the Wee1 inhibitor Adavosertib through Myt1 upregulation. Cancer Res. 79(23): 5971-5985, 2019
17. Bukhari A.B., Lewis C.W., Pearce J.J., Luong D., Chan G.K., Gamper A.M. Inhibiting Wee1 and ATR kinases produces tumor-selective synthetic lethality and suppresses metastasis. J. Clin. Invest. 129(3):1329-1344, 2019
16. Moiseeva T., Gamper A.M., Hood B., Conrads T., Bakkenist C.J. Human DNA polymerase epsilon is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 and MMS19. DNA Repair 43: 9-17, 2016
15. Hu D., Gur M., Zhou Z., Gamper A., Hung M.C., Fujita N., Lan L., Bahar I., Wan Y. Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis. Nat. Commun. 6: 2015
14. Kwun H.J., Shuda M., Camacho C., Gamper A., Thant M., Chang Y., and Moore P.S. Restricted Protein Phosphatase 2A Targeting by Merkel Cell Polyomavirus Small T Antigen. J. Virol. 89(8):4191-200, 2015.
13. Gamper A.M., Rofougaran R., Watkins S.C., Greenberger J.S., Beumer J.H., Bakkenist C.J. ATR kinase activation in G1 phase facilitates the repair of ionizing radiation-induced DNA damage. Nucleic Acids Res. 41:10334-442013, 2013.
12. Gamper A.M., Choi S., Matsumoto Y., Banerjee D., Tomkinson A.E., Bakkenist C.J. ATM physically and functionally interacts with PCNA to regulate DNA synthesis. J. Biol. Chem. 287: 12445-12454, 2012.
11. Gamper A.M., Qiao X., Kim J., Zhang L., DeSimone M.C., Rathmell W.K., Wan Y. Regulation of KLF4 turnover reveals an unexpected tissue specific role of pVHL in tumorigenesis. Mol. Cell 45: 233-243, 2012.
10. Choi S., Gamper A.M., White J.S., Bakkenist C.J. Inhibition of ATM kinase activity does not phenocopy ATM protein disruption: implications for the clinical utility of ATM kinase inhibitors. Cell Cycle 9: 4052-4057, 2010.
9. Qiao X., Zhang L., Gamper A.M., Fujita T. Wan Y. APC/C-Cdh1: From cell cycle to cellular differentiation and genomic integrity. Cell Cycle 9: 3904 - 3912, 2010. (Review)
8. Gamper A.M., Kim J., & Roeder R.G. The STAGA subunit hADA2b is an important regulator of hGCN5 catalysis. Mol. Cell. Biol. 1: 266-80, 2009.
7. Gamper A.M., Roeder R.G. Multivalent Binding of p53 to the STAGA Complex mediates Coactivator Recruitment after UV Damage. Mol. Cell. Biol. 8: 2517-27, 2008.
6. Palhan V., Chen S., Peng G.H., Tjernberg A., Gamper A.M., Chait B.T., La Spada A.R., Roeder R.G. Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration. Proc. Natl. Sci. Acad. USA. 102: 8472-7, 2005.
5. Martinez E., Palhan V., Tjernberg A., Lymar E.S., Gamper A.M., Kundu T.K., Chait B.T., Roeder R.G. Human STAGA Complex is a Chromatin-Acetylating Transcription Coactivator that Interacts with Pre-mRNA Splicing and DNA Damage-Binding Factors In Vivo. Mol. Cell. Biol. 21: 6782-95, 2001.
4. Gamper A.M., Winger R.H., Liedl K.R., Sotriffer C.A., Varga J.M., Kroemer R.T., Rode B.M. Comparative molecular field analysis of haptens docked to the multispecific antibody IgE(Lb4). J. Med. Chem. 39: 3882-3888, 1996.
3. Winger R.H., Liedl K.R., Sotriffer C.A., Gamper A.M., Rode B.M., Kroemer R.T., Varga J.M. Prediction of IgE(Lb4)-ligand complex structures by automated docking. J. Molec. Recognition 9: 239-246, 1996.
2. Sotriffer C.A., Liedl K.R., Winger R.H., Gamper A.M., Kroemer R.T., Linthicum D.S., Rode B.M., Varga J.M. Heteroligation of a mouse monoclonal IgE antibody (La2) with small molecules, analysed by computer-aided automated docking. Mol. Immunol. 33: 129-144, 1996.
1. Armesto X.L., Canle M., Gamper A.M., Losada M., Santaballa J.A. Acid-base equilibria and decomposition of secondary (N-Cl)-alpha-amino acids. Tetrahedron 50: 10509-10520, 1994.
28. Sokhi S., Lewis C.W., Bukhari A.B., Hadfield J., Xiao E.J., Fung J., Yoon Y.J., Hsu W.-H., Gamper A.M.*, Chan G.K.* Myt1 overexpression mediates resistance to Cell Cycle and DNA damage checkpoint kinase inhibitors. Front. Cell Dev. Biol. 2023 Nov 2;11:1270542. *corresponding authors
27. Storozynsky Q.T., Han X., Komant S., Agopsowicz K.C., Potts K.G., Gamper A.M., Godbout R., Evans D.H., Hitt M.M. Radiation-Induced Cellular Senescence Reduces Susceptibility of Glioblastoma Cells to Oncolytic Vaccinia Virus. Cancers 2023 Jun 25;15(13):3341
26. Storozynsky Q.T., Agopsowicz K.C., Noyce R.S., Bukhari A.B., Han X., Snyder N., Umer B.A., Gamper A.M., Godbout R., Evans D.H., Hitt M.M. Radiation combined with oncolytic vaccinia virus provides pronounced antitumor efficacy and induces immune protection in an aggressive glioblastoma model. Cancer Lett. 2023 May 28;562:216169. doi: 10.1016/j.canlet.2023.216169
25. Zhou J., Kong Y.S., Vincent K.M., Dieters-Castator D., Bukhari A.B., Glubrecht D., Liu R.Z., Quilty D., Findlay S.D., Huang X., Xu Z., Yang R.Z., Zhang L., Tang E., Lajoie G., Eisenstat D.D., Gamper A.M., Fahlman R., Godbout R., Postovit L.M., Fu Y. RNA cytosine methyltransferase NSUN5 promotes protein synthesis and tumorigenic phenotypes in glioblastoma. Mol Oncol. 2023 Apr 14. doi: 10.1002/1878-0261.13434.
24. Chow B., Warkentin B., Nanda K., Ghosh S., Huang F., Gamper A.M., Menon G. Radiobiological Response to Brachytherapy: Cervical Squamous Cell Carcinoma Versus Adenocarcinoma Parameters, Quantified in Vitro. Radiotherapy and Oncology 174, S25-S26, 2022
23. Bukhari A.B, Chan G.K., Gamper A.M. Targeting the DNA Damage Response for Cancer Therapy by Inhibiting the Kinase Wee1. Front. Oncol. 2022; 12:828684.
22. Sadat S.M.A., Wuest M, Paiva I.M., Munira S., Sarrami N., Sanaee F., Yang X., Paladino M., Binkhathlan Z., Karimi-Busheri F., Martin G.R., Jirik F.R., Murray D., Gamper A.M., Hall D.G., Weinfeld M., Lavasanifar A., Nano-Delivery of a Novel Inhibitor of Polynucleotide Kinase/Phosphatase (PNKP) for Targeted Sensitization of Colorectal Cancer to Radiation-Induced DNA Damage. Front. Oncol. 2021; 11: 772920.
21. Chow B., Warkentin B., Nanda K., Huang F., Gamper A.M., Menon G., BAIRDA: A novel in vitro setup to quantify radiobiological parameters for cervical cancer brachytherapy dose estimations. Phys. Med. Biol., 2022; 67(4)
20. Chow B., Warkentin B., McEwen M., Huang F., Nanda K., Gamper A.M., Menon G., Uncertainties associated with clonogenic assays using a Cs-137 irradiator and Ir-192 afterloader: A comprehensive compilation for radiation researchers. Rad. Res. 2022, Apr 7. doi: 10.1667/RADE-21-00205.1
19. Bilyk O., Hamedi B., Dutta I., Newell M., Bukhari A.B., Gamper A.M., McVea R.C., Liu J., Schueler J., Siegers G.M., Field C.J., and Postovit L.-M.
Docosahexaenoic acid in the Inhibition of Tumor Cell Growth in preclinical models of ovarian cancer. Nutr. Cancer, 74(4):1431-1445, 2022
18. Lewis C.W., Bukhari A.B., Xiao E.J., Choi W-S., Smith J.D., Homola E., Mackey J.R., Campbell S.D., Gamper A.M., Chan G.K. Cancer cells acquire
resistance to the Wee1 inhibitor Adavosertib through Myt1 upregulation. Cancer Res. 79(23): 5971-5985, 2019
17. Bukhari A.B., Lewis C.W., Pearce J.J., Luong D., Chan G.K., Gamper A.M. Inhibiting Wee1 and ATR kinases produces tumor-selective synthetic lethality and suppresses metastasis. J. Clin. Invest. 129(3):1329-1344, 2019
16. Moiseeva T., Gamper A.M., Hood B., Conrads T., Bakkenist C.J. Human DNA polymerase epsilon is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 and MMS19. DNA Repair 43: 9-17, 2016
15. Hu D., Gur M., Zhou Z., Gamper A., Hung M.C., Fujita N., Lan L., Bahar I., Wan Y. Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis. Nat. Commun. 6: 2015
14. Kwun H.J., Shuda M., Camacho C., Gamper A., Thant M., Chang Y., and Moore P.S. Restricted Protein Phosphatase 2A Targeting by Merkel Cell Polyomavirus Small T Antigen. J. Virol. 89(8):4191-200, 2015.
13. Gamper A.M., Rofougaran R., Watkins S.C., Greenberger J.S., Beumer J.H., Bakkenist C.J. ATR kinase activation in G1 phase facilitates the repair of ionizing radiation-induced DNA damage. Nucleic Acids Res. 41:10334-442013, 2013.
12. Gamper A.M., Choi S., Matsumoto Y., Banerjee D., Tomkinson A.E., Bakkenist C.J. ATM physically and functionally interacts with PCNA to regulate DNA synthesis. J. Biol. Chem. 287: 12445-12454, 2012.
11. Gamper A.M., Qiao X., Kim J., Zhang L., DeSimone M.C., Rathmell W.K., Wan Y. Regulation of KLF4 turnover reveals an unexpected tissue specific role of pVHL in tumorigenesis. Mol. Cell 45: 233-243, 2012.
10. Choi S., Gamper A.M., White J.S., Bakkenist C.J. Inhibition of ATM kinase activity does not phenocopy ATM protein disruption: implications for the clinical utility of ATM kinase inhibitors. Cell Cycle 9: 4052-4057, 2010.
9. Qiao X., Zhang L., Gamper A.M., Fujita T. Wan Y. APC/C-Cdh1: From cell cycle to cellular differentiation and genomic integrity. Cell Cycle 9: 3904 - 3912, 2010. (Review)
8. Gamper A.M., Kim J., & Roeder R.G. The STAGA subunit hADA2b is an important regulator of hGCN5 catalysis. Mol. Cell. Biol. 1: 266-80, 2009.
7. Gamper A.M., Roeder R.G. Multivalent Binding of p53 to the STAGA Complex mediates Coactivator Recruitment after UV Damage. Mol. Cell. Biol. 8: 2517-27, 2008.
6. Palhan V., Chen S., Peng G.H., Tjernberg A., Gamper A.M., Chait B.T., La Spada A.R., Roeder R.G. Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration. Proc. Natl. Sci. Acad. USA. 102: 8472-7, 2005.
5. Martinez E., Palhan V., Tjernberg A., Lymar E.S., Gamper A.M., Kundu T.K., Chait B.T., Roeder R.G. Human STAGA Complex is a Chromatin-Acetylating Transcription Coactivator that Interacts with Pre-mRNA Splicing and DNA Damage-Binding Factors In Vivo. Mol. Cell. Biol. 21: 6782-95, 2001.
4. Gamper A.M., Winger R.H., Liedl K.R., Sotriffer C.A., Varga J.M., Kroemer R.T., Rode B.M. Comparative molecular field analysis of haptens docked to the multispecific antibody IgE(Lb4). J. Med. Chem. 39: 3882-3888, 1996.
3. Winger R.H., Liedl K.R., Sotriffer C.A., Gamper A.M., Rode B.M., Kroemer R.T., Varga J.M. Prediction of IgE(Lb4)-ligand complex structures by automated docking. J. Molec. Recognition 9: 239-246, 1996.
2. Sotriffer C.A., Liedl K.R., Winger R.H., Gamper A.M., Kroemer R.T., Linthicum D.S., Rode B.M., Varga J.M. Heteroligation of a mouse monoclonal IgE antibody (La2) with small molecules, analysed by computer-aided automated docking. Mol. Immunol. 33: 129-144, 1996.
1. Armesto X.L., Canle M., Gamper A.M., Losada M., Santaballa J.A. Acid-base equilibria and decomposition of secondary (N-Cl)-alpha-amino acids. Tetrahedron 50: 10509-10520, 1994.
